Microcytosis in ankank mice and the role of ANKH in promoting erythroid differentiation》.pdfVIP

E X P E R I M E N T A L C E L L R E S E A R C H 3 1 3 ( 2 0 0 7 ) 4 1 2 0 – 4 1 2 9 ava i l a b l e a t w w w. s c i e n c e d i r e c t . c o m w w w. e l s ev i e r. c o m / l o c a t e / yexc r Research Article Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation a b a b c John Wang , Chen Wang , Hing Wo Tsui , Facundo Las Heras , Emily Y. Cheng , d a a,c Norman N. Iscove , Basil Chiu , Robert D. Inman , Kenneth P.H. Pritzkerb, Florence W.L. Tsuia,c,⁎ aGenetics and Development Division, Toronto Western Research Institute, Toronto, Ontario, Canada bPathology and Laboratory Medicine, Mount Sinai Hospital and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada cDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada dThe Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada A R T I C L E I N F O R M A T I O N A B S T R A C T Article Chronology: Progressive ankylosis (Ank and the human homolog, ANKH) is a transmembrane protein Received 19 March 2007 which regulates transport of inorganic pyrophosphate (PPi). ank/ank mice with a mutated ank Revised version received gene, have calcification and bone ankylosis of the affected joints. In the course of studying 11 September 2007 these mutant