Involvement of aberrant miR-139Jun feedback loop in human gastric cancer》.pdfVIP

Biochimica et Biophysica Acta 1853 (2015) 481–488 Contents lists available at ScienceDirect Biochimica et Biophysica Acta jour nal homepage: www.e lsevie r. com/ locate/ bbamcr Involvement of aberrant miR-139/Jun feedback loop in human gastric cancer Yan Zhang a,1, Wen-Long Shen a,1, Ming-Lei Shi a,1, Le-Zhi Zhang a, Zhang Zhang a, Ping Li a, Ling-Yue Xing a,b, Feng-Yan Luo a, Qiang Sun a,⁎, Xiao-Fei Zheng c, Xiao Yang d,⁎⁎, Zhi-Hu Zhao a,⁎⁎⁎ a Institute of Biotechnology, Beijing 100071, China b School of Life Science, Anhui University, Hefei 230601, China c Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850, China d State Key Laboratory of Proteomics, Genetic Laboratory of Development and Disease, Institute of Biotechnology, Beijing 100071, China a r t i c l e i n f o a b s t r a c t Article history: Accumulating evidence indicates that some miRNAs could form feedback loops with their targets to fine-tune Received 1 June 2014 tissue homeostasis, while disruption of these loops constitutes an essential step towards human tumorigenesis. Received in revised form 28 November 2014 In this study, we report the identification of a novel negative feedback loop formed between miR-139 and its on- Accepted 2 December 2014 cogenic target Jun. In this loop, miR-139 could inhibit Jun expression by targeting a conserved site on its 3′-UTR, Available online 10 December 2014 whereas Jun could induce miR-139 expression in a dose dep