Kinetics of HDL-apo A-I in the WHHL rabbit, an animal model of familial hypercholesterolemia》.pdfVIP
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Kinetics of HDL-apo A-I in the WHHL rabbit, an animal model of familial hypercholesterolemia》.pdf
Atherosclerosis, 19 (1989) 225-230 225 Elsevier Scientific Publishers Ireland, Ltd. ATHERO 04382 Kinetics of HDL-apo A-I in the WHHL rabbit, an animal model of familial hypercholesterolemia Keijiro Saku I, Kyosuke Yamamoto 2, Takahiro Sakai 2, Teruyoshi Yanagida 3, Kazuko Hidaka I, Jun Sasaki ’ and Kikuo Arakawa ’ ’Department of InternalMedicine, School of Medicine, Fukuoka Uniuerstty, Fukuoka (Japan), ’Department of Internal Medicine. School of Medicine, Saga Medical College, and 3 Faculty of Agriculture, Saga University, Saga (Japan) (Received 14 April, 1989) (Revised, received 7 June. 1989) (Accepted 21 June. 1989) Summary Plasma high density lipoproteins (HDL) and their major protein, apolipoprotein (apo) A-I, are deficient in homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits. As the pathophysiology of subnor- mal HDL-apo A-I is unclear, we examined kinetic parameters of HDL-apo A-I in WHHL rabbits and normolipidemic Japanese White (control) rabbits. The total plasma mass of HDL-apo A-I was signifi- cantly smaller (P 0.01) in WHHL rabbits than in controls
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