Knockdown of ZFX inhibits gastric cancer cell growth in vitro and in vivo via downregulating the ERK-MAPK pathway》.pdfVIP

Cancer Letters 337 (2013) 293–300 Contents lists available at SciVerse ScienceDirect Cancer Letters journal homepage: www.else /locate/canlet Knockdown of ZFX inhibits gastric cancer cell growth in vitro and in vivo via downregulating the ERK-MAPK pathway Shuai Wu a,b,c,1, Xin-Yuan Lao d,1, Tian-Tian Sun a,b,c, Lin-Lin Ren a,b,c, Xuan Kong a,b,c, Ji-Lin Wang a,b,c, Ying-Chao Wang a,b,c, Wan Du a,b,c, Ya-Nan Yu a,b,c, Yu-Rong Weng a,b,c, Jie Hong a,b,c,⇑, Jing-Yuan Fang a,b,c,⇑ a GI Division, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institution of Digestive Disease, 145 Middle Shandong Rd., Shanghai 200001, China b Key Laboratory of Gastroenterology Hepatology, Ministry of Health, Shanghai Jiao-Tong University, 145 Middle Shandong Rd., Shanghai 200001, China c State Key Laboratory of Oncogene and Related Genes, 145 Middle Shandong Rd., Shanghai 200001, China d Holly Lab Shanghai, Shanghai 200233, China a r t i c l e i n f o a b s t r a c t Article history: Zinc finger protein X-linked (ZFX) is a zinc finger transcription factor encoded on the X chromosome. Received 20 December 2012 Here, we found that ZFX expression was significantly upregulated in gastric cancer (GC) cell lines and tis- Received in revised form 26 March 2013 sues. Knockdown of ZFX induced significant apoptosis and cell cycle arrest in SGC7901 and MGC803 cells. Accepted 5 April 2013 Moreover, we demonstrated for the first time that knockdown of ZFX inhibited gastric cancer cell growth