Immunoregulatory and antitumor activity of schizophyllan under ultrasonic treatment》.pdfVIP

International Journal of Biological Macromolecules 80 (2015) 302–308 Contents lists available at ScienceDirect International Journal of Biological Macromolecules j o u r na l h o me p a g e : w w w. elsev /locate/ijbiomac Immunoregulatory and antitumor activity of schizophyllan under ultrasonic treatment Kui Zhong a,b , Litao Tong a,b , Liya Liu a,b , Xianrong Zhou a,b , Xingxun Liu a,b , Qi Zhang a,b , Sumei Zhou a,b,∗ a Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences, PR China b Key Laboratory of Agro-Products Processing, Ministry of Agriculture, P.O. Box 5109, Beijing 100193, PR China a r t i c l e i n f o a b s t r a c t Article history: Aim of this study was to investigate the effect of ultrasonic treatment on the biological activities Received 14 April 2015 of schizophyllan (SPG) from Schizophyllum commune. The immunoregulatory and antitumor activity Received in revised form 9 June 2015 in vitro and in vivo of SPG and ultrasonic-treated SPG (USPG) were evaluated by splenic lymphocytes, Accepted 26 June 2015 macrophages RAW264.7 and human breast carcinoma T-47D cells. Compared with SPG, USPG fractions Available online 28 June 2015 had small molecular weight and narrow distribution. Meantime, more enhancement of NO production in macrophages RAW264.7, lymphocytes proliferation rates, IL-2 and TNF- level from spleen lympho- Keywords: