Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic AktGSK3 pathways in hyperhomocysteinemic mice》.pdfVIP

Biochimica et Biophysica Acta 1832 (2013) 718–728 Contents lists available at SciVerse ScienceDirect Biochimica et Biophysica Acta journal homepage: www.else vi er. com/ locate /bbadis Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice Asma Tlili a, Frank Jacobs b, Leanne de Koning c, Sirine Mohamed a, Linh-Chi Bui a, d, Julien Dairou a, d, Nicole Belin e, Véronique Ducros e, Thierry Dubois f, Jean-Louis Paul g, h, Jean-Maurice Delabar a, Bart De Geest b, Nathalie Janel a,⁎ a Univ Paris Diderot, Sorbonne Paris Cité, Unit of Functional and Adaptative Biology (BFA), EAC-CNRS 4413, 75013 Paris, France b Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium c RPPA Platform, Institut Curie Department of Translational Research, 75248 Paris cedex 05, France d BioProfi ler-UFLC Facilities, Univ Paris Diderot, Sorbonne Paris Cité, BFA, EAC-CNRS 4413, 75013 Paris, France e Département de Biochimie Toxicologie Pharmacologie, IBP-CHU de Grenoble, 38043 Grenoble cedex 9, France f Breast Cancer Biology Group, Institut Curie Department of Translational Research, 75248 Paris cedex 05, France g AP-HP, Hôpital Européen Georges Pompidou, Service de Biochimie, 75015 Paris, France h Univ Paris-Sud, EA 4529, UFR de Pharmacie, 92296 Châtenay-Malabry, France a r t i c l e i n f o a b s t r a c t Article history: Hyperhomocysteinemia, characterized by high plasma homocysteine levels, is recognized as an independent risk Received 26 January 2013 factor for cardiovascular dis