HMGB1 expression patterns during the progression of experimental autoimmune encephalomyelitis》.pdfVIP

Journal of Neuroimmunology 280 (2015) 29 –35 Contents lists available at ScienceDirect Journal of Neuroimmunology j ournal homepage: www.el sevier. com/l o cate/ jneuroim HMGB1 expression patterns during the progression of experimental autoimmune encephalomyelitis Yan Sun a,b, Huoying Chen a, Jiapei Dai b, Huijuan Zou a, Ming Gao a, Hao Wu a, Bingxia Ming a, Lin Lai a, Yifan Xiao a, Ping Xiong a, Yong Xu a, Feili Gong a, Fang Zheng a,⁎ a Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China b Wuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan 430074, China a r t i c l e i n f o a b s t r a c t Article history: High mobility group box 1 (HMGB1), a nonhistone chromatin associated protein, plays different roles according Received 8 January 2015 to the expression pattern such as the amount, cell location and sub-cellular location. It has been recently demon- Received in revised form 9 February 2015 strated that the systemic HMGB1 is associated with autoimmune encephalomyelitis. However, the dynamic Accepted 23 February 2015 change of HMGB1 expression pattern in spinal cords that may be involved in the progression of disease is not fully understood. In this study, the amount, cell location and subcellular location of HMGB1 in adult mice spinal Keywords: cords during various stages of experi