Exposure to sodium tungstate and Respiratory Syncytial Virus results in hematologicalimmunological disease in C57BL6J mice》.pdfVIP

Chemico-Biological Interactions 196 (2012) 89–95 Contents lists available at ScienceDirect Chemico-Biological Interactions journal homepage: www.elsevier.c om/locate/chembioint Exposure to sodium tungstate and Respiratory Syncytial Virus results in hematological/immunological disease in C57BL/6J mice Cynthia D. Fastje a,⇑, Kevin Harper a, Chad Terry a, Paul R. Sheppard b, Mark L. Witten a,1 a Steele Children’s Research Center, PO Box 245073, University of Arizona, Tucson, AZ 85724-5073, USA b Laboratory of Tree-Ring Research, PO Box 210058, University of Arizona, Tucson, AZ 85721-0058, USA a r t i c l e i n f o a b s t r a c t Article history: The etiology of childhood leukemia is not known. Strong evidence indicates that precursor B-cell Acute Available online 1 May 2011 Lymphoblastic Leukemia (Pre-B ALL) is a genetic disease originating in utero. Environmental exposures in two concurrent, childhood leukemia clusters have been profiled and compared with geographically Keywords: similar control communities. The unique exposures, shared in common by the leukemia clusters, have Tungsten been modeled in C57BL/6 mice utilizing prenatal exposures. This previous investigation has suggested Respiratory Syncytial Virus in utero exposure to sodium tungstate (Na2WO4 ) may result in hematological/immunological disease Childhood leukemia through genes associated with viral defense. The wor