壳聚糖及其季铵盐对牙周常见致病菌的体外抑菌活性.pdfVIP

47 1 V ol. 47, N o. 1 20 11 2 A CT A A CA DEM IA E M ED ICIN AE Q IN G DA O U N IV ERS IT A T IS Feb ruary 20 11 壳聚糖及其季铵盐对牙周常见致病菌的体外抑菌活性 , , , ( , 266003) ] ( CS) ( H T CC) 3 CS H T CC ( M IC) HT CC CS 3 , M IC 0. 5 ~ 2 . 5 g / L H T CC H T CC CS ( F = 15. 365~ 40. 266, q= 5. 387 ~ 9. 8 12, P 0. 05) H T CC 3 , ] ; ; ; ] R78 1. 42 ] A ] 20 11) 0 1002303 INVITRO BACTERIOSTASIS OF CHITOSAN AND QUATERNIZED CHITOSAN ON COMMONLYSEEN PERIODONTAL PATHO GENS JI QI UX IA , X U Q UA N CH EN , Y U X I N B O, YUA N CH A N GQI N G ( D epart ment of S t om at ology , T he A f fil iat ed H ospit al of Q ingdao U n iversit y M edi cal Coll ege , Q ingdao 266003, China) [ABSTRACT] Obj ect ive T o evaluat e t he bact eriost as is of chit osan ( CS ) an d qu at ernized chit osan ( H T C C) on t hree com m on lys een periodont al pat hogen ic bact eria . Met hod s A n agar dif f usion met h od w as u sed t o m easure t he ant imicrobial propert y of CS and H T CC, such as t he min imal inhib it ory concent rati on ( M IC) and in hibit ory zone again st P . gingivalis, P. int erm edia an d A. act inomy cet emcomit ans . Resul ts T hree periodon tal pat hogen s w er e su scept ible to CS an d HT CC w it h M ICs ran gi ng f rom 0. 5 t o 2. 5 g/ L . T h e lact ic acid ( LA ) solut ion of H T CC processed larger inhibit ory z on e t han t h os e of LA s olut ion of CS and aque ous solu tion of HT CC ( F = 15. 365- 40. 266; q= 5. 387- 9. 812; P 0. 05) . Concl usion T he peri odont al pat hogen s t est ed i n t he st udy are su scept ible t o H T CC w h ich lay t he f oundat ion f or th e fi eld of period on tal t reat ment . [KEY WORDS] quat erniz ed chit osan; chit osan; periodont al dis