海藻酸壳聚糖聚乳酸羟乙醇酸复合微球的制备及其对蛋白释放的调节.pdfVIP

# 182# A c ta Pharm aceutica S in ica 2005, 40 ( 2) : 182- 186 -- 1, 2 1* 2 郑彩虹 , 梁文权 , 虞和永 ( 1. , 31003 1; 2. , 3 10006) : -- ( PLGA ) , , -, PLGA BCA , , 30 Lm, PLGA , 60% - 70% 80% 1 h 40% - 50% 25% , 5% --PLGA , , PLGA : ; ; ; -; : R 943. 4 1 : A : 0513- 4870 ( 2005) 02- 0182- 05 Preparation of alginate-chitosan-poly ( lactic-co-glycolic acid) composite microsphere and its regulation ofprotein release 1, 2 1* 2 ZHENG Ca-i hong , L IANG W en-qu an , YU H e-yong (1. Institu te of P harm aceutics, Zhej iang University, Hangzhou 310031, China; . Obstetric and Gynecology H osp italAff iliated to Zhej iang University, Hangzhou 310006, China) Abstract: Aim T o e levate the encap su lation effic iency, decrease the burst release and mi prove the re lease of prote in entrapped in po ly ( lactic-co-g lyco lic acid) ( PLGA ) m icrospheres. The bov ine serum a lbum in ( BSA ) com posite m icrospheres o f alg inate- chitosan-PLGA w ere prepared and the release characteristics of BSA from th is com posite m icrospheres were stud ied. Methods The m uch sm aller calc ium alg inate m icrocapsules w ere first prepared by a m od ified em u lsification m ethod in an isopropy l a lcoho l-w ashed w ay and coated w ith chitosan, then the a lg inate-ch itosan m icrocap su les w ere further entrapped in PLGA to form t