肾移植术后不同晶体液对酸碱平衡和早期肾功能的影响.pdfVIP

The Effect of Different Crystalloid Solutions on Acid-Base Balance and Early Kidney Function After Kidney Transplantation Necmiye Hadimioglu, MD* BACKGROUND: This study aimed to quantify changes in acid-base balance, potassium and lactate levels as a function of administration of different crystalloid solutions Iman Saadawy, MD† during kidney transplantation, and to determine the ideal fluid for such patients. METHODS: In this double-blind study, patients were randomized to three groups Tayyup Saglam, MD* (n 30 each) to receive either normal saline, lactated Ringer’s, or Plasmalyte, all at 20–30 mL kg1 h 1. Arterial blood analyses were performed before induction of anesthesia, and at 30-min intervals during surgery, and total IV fluids recorded. Zeki Ertug, MD* Urine volume, serum creatinine and BUN, and creatinine clearance were recorded on postoperative days 1, 2, 3, and 7. Ayhan Dinckan, MD‡ RESULTS: There was a statistically significant decrease in pH (7.44 0.50 vs 7.36 0.05), base excess (0.4 3.1 vs –4.3 2.1), and a significant increase in serum chloride (104 2 vs 125 3 mM/L) in patients receiving saline during surgery. Lactate levels increased significantly in patients who received Ringer’s lactate (0.48 0.29 vs 1.95 0.48). No significant changes in acid-base measures or lactate levels