甘露聚糖肽注射液致过敏性休克.pdfVIP

中国药物应用与监测 2014 年6 月第11卷第3 期 Chinese Journal of Drug Application and Monitoring, Vol.11, No.3, June 2014 ·病例监测 · 甘露聚糖肽注射液致过敏性休克 金淑君，赵　艳（解放军总医院肾病科，北京 100853 ） [摘要]　1例54 岁女性患者，既往无食物、药物过敏史，因膜性肾病Ⅰ期8 个月给予甘露聚糖肽注射液。用药2 min 后，患者 -1 ，氧饱和度92% ，BP 116/69 mm Hg ，吸气时可闻及明显喘鸣音，面部及球 出现呼吸困难、胸闷、憋气等症状，HR 90 次·min 结膜充血，双前臂皮肤色红，无皮疹。立即停止输入，更换输液器，并给予吸氧，抗过敏及扩充血容量治疗。40 min 后，患者 上述症状缓解，皮肤颜色正常，面部及球结膜充血消失。 [关键词]　甘露聚糖肽注射液；过敏性休克；药品不良反应 [ 中图分类号]　R969.3　　 [ 文献标识码]　B　 [ 文章编号]　1672 – 8157(2014)03 – 0189 – 02 Allergic shock induced by mannatide injection JIN Shu-jun, ZHAO Yan(Department of Nephrology, PLA General Hospital, Beijing 100853, China) [ABSTRACT]　One 54-year-old female patient without allergic history of food and drug was diagnosed as stage I membranous nephropathy. Mannatide injection was given to the patient. Two minutes later, the patient presented with dyspnea, chest congestion, breathlessness with HR of 90 bites per minute, SpO2 of 92%, BP of 116/69 mm Hg. Clearly wheezing when inhaling, congestion of face and bulbar conjunctiva, red skin in arms without rash were observed. So the medicine was immediately stopped, infusion apparatus were replaced, the inhalation of oxygen, anti-allergic therapy and the rescue of blood volume expansion were given. Forty minutes later, the symptoms alleviated, the colour of skin was normal, the hyperemia of face and bulbar conjunctiva disappeared. [KEY WORDS]　Mannatide injection; Allergic shock; Adverse drug reaction -1 1　临床资料 批号12116 ），滴速为60 滴·min ，2 min 后，患者出现 患者，女性，54 岁，因膜性肾病 Ⅰ期8 个月，为 呼吸困难、胸闷、憋气等症状，吸气时可闻及明显喘 行进一步治疗于2013 年6 月24 日入院。查体：浅表 鸣音，面部及球结膜充血，双前臂皮肤色红，无皮疹。 淋巴结不大，心肺听诊无异常，腹软，肝脾未及，四