半夏-夏枯草配伍对葫芦巴碱、尿嘧啶、腺苷煎出量的影响.pdfVIP

2014年 5月第 21卷第 5期 中国中医药信息杂志 ·71· ·中药研究与开发 · 半夏-夏枯草配伍对葫芦巴碱、尿嘧啶、腺苷煎出量的影响 张俊义,张晓静,孙毅坤 北京中医药大学,北京 100102 摘要：目的 研究半夏-夏枯草不同比例配伍对葫芦巴碱、尿嘧啶及腺苷煎出量的影响,探索其变化规律及 合理配伍。方法 采用高效液相色谱法同时测定半夏和夏枯草不同比例配伍时葫芦巴碱、尿嘧啶及腺苷的煎出 量,并通过比较分析不同配伍比例对 3 种成分煎出量的影响。结果 半夏配伍夏枯草,尿嘧啶及腺苷煎出量增 加,葫芦巴碱在两者配伍情况下煎出量减少。结论 半夏-夏枯草不同配伍对葫芦巴碱、尿嘧啶、腺苷煎出量有 一定影响,最佳配伍比例值得深入研究。 关键词：半夏；夏枯草；中药配伍；葫芦巴碱；尿嘧啶；腺苷 DOI：10.3969/j.issn.1005-5304.2014.05.022 中图分类号：R284.1 文献标识码：A 文章编号：1005-5304(2014)05-0071-03 Effect of Pinelliae Rhizoma Combined with Prunellae Spica in Different Ratios on Decoction Yield of Trigonelline, Uracil and Adenosine ZHANG Jun-yi, ZHANG Xiao-jing, SUN Yi-kun (Beijing University of Chinese Medicine, Beijing 100102, China) Abstract ：Objective To study the effect of Pinelliae Rhizoma combined with Prunellae Spica in different ratios on the decoction yield of trigonelline, uracil and adenosine, and to investigate the disciplines of various compatibilities. Methods HPLC was used to determine the decoction yield of trigonelline, uracil and adenosine with different ratios of Pinelliae Rhizoma and Prunellae Spica. The influence of various compatibilities on the decoction yield of three components was analyzed. Results Combined with Prunellae Spica, the uracil and adenosine were increased in the decoction yield with Pinelliae Rhizoma, while the decotion yield of trigonelline was decreased. Conclusion The dectotion yield of trigonelline, uracil and adenosine were affected by the different ratios of Pinelliae Rhizoma and Prunellae Spica. The suitable compatibility need more research. Key words ：Pinelliae Rhizoma ；Prunellae Spica ；compatibility of Chinese medicine ；trigonelline ； uracil ；adenosine 半夏为天南星科植物半夏 Pinellia ternata 基金项目：国家自然科学基金