文献_2012-The Impact in Older Women of Ovarian FMR1 Genotypes and Sub-Genotypes on Ovarian Reserve.pdfVIP

The Impact in Older Women of Ovarian FMR1 Genotypes and Sub-Genotypes on Ovarian Reserve 1 1,2 1 1,3 Norbert Gleicher *, Andrea Weghofer , Ann Kim , David H. Barad * 1 Center for Human Reproduction (CHR) and Foundation for Reproductive Medicine, New York, New York, United States of America, 2 Department of Gynecological Endocrinology and Reproductive Medicine, Medical University Vienna, Vienna, Austria, 3 Department of Epidemiology and Social Medicine and Department of Obstetrics, Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, New York, United States of America Abstract We recently associated ovarian FMR1genotypes and sub-genotypes with distinct ovarian aging patterns. How they impact older females is, however, unknown. We, therefore, investigated 217 consecutive first in vitro fertilization (IVF) cycles in ¨ women .40 assessing oocyte yields, stratified for better (anti-Mullerian hormone, AMH .1.05 ng/mL) or poorer (AMH#1.05 ng/mL) functional reserve (FOR)). Mean age was 42.462.0 years, mean AMH 0.7660.92 ng/mL and mean oocyte yield 5.365.4. Overall, and in women with better FOR, FMR1 did not affect oocyte yields. With poorer FOR (AMH#1.05 ng/mL) women with het-norm/high, however, demonstrated higher oocyte yields (5.0 63.8) than those with het- norm/low sub-genotype 3.162.5; P = 0.03), confirmed after log conversion. Known associated with low FOR at young age, het-norm/high, thus, appears to preserve FOR into older age, and both het sub-genotypes appear to expand fe