文献_2012-Aromatase (CYP19) gene variants influence ovarian response to standard gonadotrophin stimulation.pdfVIP

J Assist Reprod Genet (2012) 29:203–209 DOI 10.1007/s10815-011-9673-y GENETICS Aromatase (CYP19) gene variants influence ovarian response to standard gonadotrophin stimulation Leandros A. Lazaros Elissavet G. Hatzi Nectaria V. Xita Georgios V. Makrydimas Apostolos I. Kaponis Atsushi Takenaka Ioannis P. Kosmas Nikolaos V. Sofikitis Theodoros I. Stefos Konstantinos A. Zikopoulos Ioannis A. Georgiou Received: 6 September 2011 /Accepted: 2 November 2011 /Published online: 17 November 2011 # Springer Science+Business Media, LLC 2011 Abstract alleles presented with lower serum FSH levels at the third Purpose The association of cytochrome P450 aromatase day of the menstrual cycle (p 0.001) and higher large gene CYP19(TTTA)n polymorphism with ovarian response follicle numbers (p 0.01), compared to women homozy- to FSH stimulation was explored. gous for short CYP19(TTTA)n alleles. The CYP19(TTTA)7 Methods Three hundred women undergoing medically assis- allele was associated with higher serum FSH levels (p ted reproduction and 300 women with at least one spontaneous 0.003), with lower total follicle (p 0.02) and large follicle pregnancy participated in the study. CYP19(TTTA)n polymor- numbers (p 0.03), while CYP19(TTTA)7 allele-carriers phism was genotyped, while serum hormones were deter- presented more frequently with small follicles than CYP19 mined. During oocyte retrieval, the follicular size, the follicle (TTTA)7 allele-non carriers (p 0.01). and oocyte numbers were recorded. Conclusions CYP19 genetic variants were associated with Results Six CYP19(TTTA)n alleles with 7 to 12 repeats were