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Human Reproduction Update, Vol.17, No.2 pp. 242–253, 2011 Advanced Access publication on August 21, 2010 doi:10.1093/humupd/dmq037 Implantation failure: molecular mechanisms and clinical treatment Hakan Cakmak and Hugh S. Taylor* Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA *Correspondence address. Section of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8063, USA. Tel: + 1-203 785-4005; Fax: + 1-203- 785-7819; E-mail: hugh.taylor@ Submitted on February 21, 2010; resubmitted on July 19, 2010; accepted on July 26, 2010 table of contents † Introduction † Methods † Roles of homeobox genes in implantation † Mechanisms of implantation failure in gynecological diseases Endometriosis Hydrosalpinx Leiomyoma Endometrial polyp Adenomyosis Polycystic ovarian syndrome Endometritis † Clinical assessment of endometrium Morphological analysis of the endometrium Histological analysis of the endometrium
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