GWAS肺腺癌研究.pdfVIP

l e t t e r s Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations 1,2 3 4 5 5 5 Daiki Miki , Michiaki Kubo , Atsushi Takahashi , Kyong-Ah Yoon , Jeongseon Kim , Geon Kook Lee , 5 5 3 6 6 4 Jae Ill Zo , Jin Soo Lee , Naoya Hosono , Takashi Morizono , Tatsuhiko Tsunoda , Naoyuki Kamatani , 2 7 8 1 1,9,10 Kazuaki Chayama , Takashi Takahashi , Johji Inazawa , Yusuke Nakamura Yataro Daigo . d e Lung cancer is the most common cause of death from cancer (BAT3-MSH5)20–22. These signals at 5p15, 6p21 and 15q25 have v r worldwide, and its incidence is increasing in East Asian and been refined in European populations by a GWAS that searched for e s Western countries. To identify genetic factors that modify the inherited susceptibility to specific histological types of lung cancer. In e r s risk of lung adenocarcinoma, we conducted a genome-wide this GWAS meta-analysis, rs2736100 (in TERT) was indicated to be t h association study in a Japanese cohort, with replication in associated with risk of lung adenocarcinoma, and no additional loci g i 23 r two ind