代谢组学在恶性肿瘤中的研究进展.docVIP

  代谢组学在恶性肿瘤中的研究进展# 张卓，邹丽娟** （大连医科大学附属二院肿瘤放疗科 116023） 5 10 15 20 25 30 35 40 摘要：肿瘤的发生和发展必然会影响机体的代谢，人们通过对代谢物进行定性和定量的分析 来了解肿瘤的发病机制。代谢组学在肿瘤的早期诊断尤其是无症状早期诊断方面具有无法比 拟的优势。本文概述了代谢组学的定义特点、与其它组学相比的优势，常见的技术分类、分 析方法及其在恶性肿瘤中的应用研究进展。应用代谢组学的方法在前列腺癌、卵巢癌、结直 肠肿瘤、肝脏肿瘤、肺癌、乳腺癌、宫颈癌等多种恶性肿瘤中寻找肿瘤代谢标志物以期早期 诊断肿瘤。代谢组学在肿瘤个体化治疗中的应用：在乳腺癌患者中，使用芳香化酶抑制剂抑 制雌激素合成；通过代谢组学的方法发现肿瘤患者体内氟尿嘧啶代谢途径中有关酶基因表达 差异，这一发现有助于准确预测化疗预后，并为个体化治疗方案的选择提供理论依据。 关键词：代谢组学；恶性肿瘤；早期诊断；研究进展 中图分类号：R73-34 The Reserch Progress of Metabonomics in Malignant Tumor ZHANG Zhuo, ZOU Lijuan (Radiotherapy Department of the Second Affiliated Hospital of Dalian Medical University 116023) Abstract: The development and progression of tumor inevitably influences body metabolism,we understand the the pathogenesis of tumor through the qualitative and quantitative analysis of metabolite.Metabonomics has various advantages in tumor early diagnosis especially without symptoms. This paper summarized the concepts and features of metabolism, common technical classification and analysis method research progress of application in malignant tumor. In order to diagnosis tumor early,many scholars have successfully try to use metabonomics method to found malignant tumor metabolic markers in prostate cancer ,ovarian cancer ,colorectal breast cancer, hepatocarcinoma lung cancer breast cancer and cervical cancer. Metabonomics method is applied for the individual treatment in cancer patients. Aeromatase inhibitor is used to inhibit expression of estrogen in the body of breast cancer patients. Metabolic enzymes gene of fluoropyrimidines was found different express by metabonomics method，which is helpful to accurately predict chemotherapy prognosis ,and provide theoretical basis for individualized treatment plan. Key words: metabolomics；malignant tumor；early diagnosis;research progress 0 引言 代谢组学是通过考察生物体系受刺激或扰动后(如将某个特定的环境变化后或基因变异) 其代谢产物发生的变化或其随时间所发生的变化,来研究生物体系的代谢途径的一种技术[1]， 它是继基因组学、转录组学、蛋白质组学后系统生物学的另一重要研究内容。代谢组学的基 本特点是整体性和全面性，它是通过所提供的信息，来解释单一或多个代谢物的研究所不能 解释的生命现象，因此