绝经后女性维生素D营养状态与体成分、骨密度和骨折风险的关系.docVIP

 Vitamin D status and its relationship with body composition, bone mineral density and fracture risk in postmenopausal 5 10 15 20 25 Central South Chinese women# Sheng Zhifeng1, Li Shuang1, Ou Yangna2* (1. Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital, Central South University, Changsha,410011; 2. Departmengt of hospital infection management, the Second Xiang-Ya Hospital, Central South University, Changsha,410011) Abstract: Aims: To assess vitamin D [25(OH)D] status and its relationship with body composition, bone mineral density (BMD), serum parathyroid level (PTH) and fracture risk, as determined using the FRAX algorithm, among postmenopausal Central South Chinese women, and to identify the risk factors for vitamin D deficiency and osteoporosis. Methods: This cross-sectional study involved 609 healthy postmenopausal Central South Chinese (28°N) women aged 50–77 years. Total body composition and BMD at the lumbar spine (L1–L4), left femur neck and total hip were measured with dual X-ray absorptiometry, and serum 25(OH)D and PTH levels, with quantitative sandwich enzyme-linked immunosorbent assay. The 10-year probabilities of a hip fracture and major osteoporotic fracture were calculated by the FRAX model. Results: Approximately 72.6% women were vitamin D deficient [25(OH)D 50 nmol/l]. Serum 25(OH)D levels did not correlate with age at menopause, PTH levels, body mass index (BMI), fat mass and weight. They positively correlated with all BMDs (P 0.05) and negatively correlated with both 10-year fracture probabilities (P 0.05). Logistic regression showed that smoking was risk factor for vitamin D deficiency. It also showed that BMI ≤19 kg/m2 and age 65 years were risk factors for osteoporosis of the lumbar spine (L1–L4), femoral neck and total hip, and 25(OH)D 50 nmol/l was a risk factor for femoral neck osteoporosis. Conclusions: Vitamin D deficiency was prevalent among postmenopausal Central South Chinese women. Smoking was a risk