第4次上课青光眼.ppt

* A total of 24 untreated patients with newly diagnosed early glaucoma and 24 age-matched controls with healthy eyes were enrolled in this study. Measurements of IOP, blood pressure, and heart rate were taken every 2 hours during a 24-hour period from the 48 subjects. In the 16-hour diurnal awake period, IOP was measured sitting and supine using a pneumatonometer, and blood pressure and heart rate were measured supine. In the 8-hour nocturnal sleep period, all measurements were taken in the supine position. Mean diurnal and nocturnal IOP in the glaucoma group were compared with data obtained from the control group with healthy eyes. In order to decrease any potential biases in collecting IOP measurements during the 24-hour period, the investigators conducted the study in a sleep laboratory, collected additional data on sleep periods prior to the study start, monitored exposure to light and physical activity, and restricted alcohol and caffeine use. The subjects were asked to maintain a daily 8-hour sleep period for 7 days before the experiment. In addition, light intensity in the laboratory was kept at a specified level and the 8-hour period of darkness in the subject’s room was adjusted to correspond to each individual’s sleep time. For subjects in both groups, nocturnal supine IOP was higher than diurnal sitting IOP. Mean diurnal IOP, either sitting or supine, was significantly higher in the glaucoma group than in the control group. 研究选择了24例未经治疗的新青光眼患者同24例正常眼对照。24小时内每隔2小时测眼压、血压和心率。在16小时的清醒时段内，眼压检测分坐位和仰卧位，血压和心率均仰卧位时检测。8小时睡眠时段内，均仰卧位检测。然后比较青光眼同正常眼的昼夜差别 为减少可能的偏崎，实验在睡眠实验室内进行，一些睡眠数据是研究开始前得到的，监测光下和活动中的数据，并限制酒精和咖啡因的摄入。检查对象被要求在研究开始前1周内保证每天8小时的睡眠。实验室内光照被控制在特定范围，而夜间光照则根据对象睡眠习惯个体化调控。 两组结果显示：夜间仰卧眼压均高于诌间坐位眼压。青光眼组的坐卧位平均昼间眼压均高于对照组 Reference: Liu JHK, Zhang X, Kripke DF, Weinreb RN. Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes. Invest Ophthalmol Vis Sci. 2003; 44:1586-1590. Liu et al., p.1588, Figure 1 Liu et al., p.1586,