CSV0C018875-hydrochloride-生命科学试剂-MCE.pdf

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CSV0C018875hydrochloride

Cat.No.:HY-133031A

CASNo.:474084-56-5

分⼦式:C₁₈H₁₈Cl₂N₂O

分⼦量:349.25

作⽤靶点:HistoneMethyltransferase

作⽤通路:Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CSV0C018875hydrochloride是⼀种G9a(EHMT2)抑制剂，具有抑制G9a活性的作⽤。CSV0C018875在酶和细

胞基础的检测中均能有效抑制G9a的活性，且其毒性远低于已知的G9a抑制剂BIX-01294。CSV0C018875紧密

结合在G9a的活性位点腔内，从⽽提⾼了结合的牢固性并延长了化合物的驻留时间，进⼀步增强了G9a的抑制

效果。CSV0C018875有潜⼒通过进⼀步优化来改善其ADME（吸收、分布、代谢和排泄）以及药效特性。

REFERENCES

[1].MRamyaChandarCharles,etal.IdentificationofnovelquinolineinhibitorforEHMT2/G9athroughvirtualscreening.Biochimie.2020

Jan;168:220-230.

[2].IdentificationofnovelquinolineinhibitorforEHMT2/G9athroughvirtualscreening

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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