Tinostamustine-hydrochloride-EDO-S101-hydrochloride-生命科学试剂-MCE.pdf

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Tinostamustinehydrochloride

Cat.No.:HY-101780A

CASNo.:1793059-58-1

Synonyms:EDO-S101hydrochloride;NL-101hydrochloride

分⼦式:C₁₉H₂₉Cl₃N₄O₂

分⼦量:451.82

作⽤靶点:HDAC

作⽤通路:CellCycle/DNADamage;Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Tinostamustinehydrochloride(EDO-S101hydrochloride)是⼀种具有抗多发性⾻髓瘤活性的化合物，具有促

进CD38表达的能⼒。Tinostamustinehydrochloride通过增加组蛋⽩H3的⼄酰化⽔平，增强肿瘤细胞对抗

CD38单克隆抗体daratumumab的敏感性。Tinostamustinehydrochloride能够增加MICA和MICB的表达，进

⽽激活NK细胞。Tinostamustinehydrochloride可以显著延迟肿瘤⽣长，提⾼⼩⿏的⽣存率。

客户使⽤本产品发表的科研⽂献

•ActaPharmacolSin.2021Apr13.

•Nutrients.2023Jun15,15(12),2760.

•IntJMolSci.2022Apr2;23(7):3980.

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REFERENCES

[1].MehrlingT,etal.TheAlkylating-HDACInhibitionFusionPrinciple:TakingChemotherapytotheNextLevelwiththeFirstinClass

MoleculeEDO-S101.AnticancerAgentsMedChem.2016;16(1):20-8.

[2].Tinostamustine(E