从萝卜青霉中分离的多糖ORP-1改善Caco-2单层细胞中与年龄相关的肠上皮屏障功能障碍.pdfVIP

Food Research International 162 (2022) 112038 Contents lists available at ScienceDirect Food Research International journal homepage: /locate/foodres Polysaccharide ORP-1 isolated from Oudemansiella raphanipes ameliorates age-associated intestinal epithelial barrier dysfunction in Caco-2 cells monolayer a, 1 a, 1 a a a a,b, * Wen-Juan Pan , Lu-Lu Shi , Yu-Ru Ren , Cheng-Ying Yao , Yong-Ming Lu , Yan Chen a School of Life Sciences, Anhui University, Hefei 230601, People ’s Republic of China b Key Laboratory for Ecological Engineering and Biotechnology of Anhui Province, Hefei 230601, People ’s Republic of China A R T I C L E I N F O A B ST R A C T Keywords: Age-associated increase in intestinal permeability is known to relate with gut microbiota dysbiosis and loss of Oudemansiella raphanipes polysaccharide ORP-1 epithelial tissue integrity. To improve healthy aging and prevent age-associated chronic disabilities, the pro- Age-associated intestinal epithelial barrier tective potential of polysaccharides from Oudemansiella raphanipes (ORP-1) against age-associated intestinal dysfunction epithelial barrier dysfunction in D-galactose-induced Caco-2 cells monolayer was investigated. In-vitro results Gut microbiota Probiotics demonstrated that ORP-1 can restore a healthy gut