微生物代谢产物对肠道屏障功能的调节.pdfVIP

REVIEW Regulation of Intestinal Barrier Function by Microbial Metabolites Sweta Ghosh, Caleb Samuel Whitley, Bodduluri Haribabu, and Venkatakrishna Rao Jala Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky SUMMARY biomarker sequencing, metagenomics, metatranscriptomics, metaproteomics, and metabolomics have facilitated the dis- Gut microbial metabolites produced proximal to intestinal covery of novel functional dynamics of microbiota2–5 and their barrier regulate numerous host responsive activities. Cur- relationship with host pathophysiology.6–9 rent review article highlights recent advances in the area of The human gut harbors abundant microbes gut metabolites and their impact on gut barrier function as ( w1012–1013) that play an important role in homeostatic well as their potential translational applications in regu- mechanisms leading to the regulation of numerous physio- lating various disorders. logical activities both in health and disease. Microbiota significantly influence the functions of the intestinal barrier that separates internal organs from harmful entities The human gastrointestinal tract (GI) harbors a diverse including microorganisms, luminal antigens, and luminal population of microbial life that continually shapes host proinflammatory factors. Intestinal barrier fun