补水柔木方结合黄体酮治疗肾虚肝郁型卵巢早衰的临床观察.docVIP

补水柔木方结合黄体酮治疗肾虚肝郁型卵巢早衰的临床观察 华方方I，夏永华2,杨君J王慧玲I,梁武凤 1 ?新乡医学院第一附属医院妇产科2.新乡医学院第一附属医院皮肤科 邮编： 453100 摘要H的观察补水柔木方结合安宫黄体酮片、单用屮药或四药治疗卵巢早衰的 疗效。方法90例肾虚肝郁型卵巢早衰患者随机分为三组，每组30例。治疗组 予补水柔木方结合安宫黄体酮片，屮药对照组单用补水柔木方，西药对照组用人 工周期法治疗。观察用药前后月经情况，根据Kupperman评分标准评判疗效并 监测血清卵泡刺激素(FSH)、黃体生成素(LH)及雌二醇(E2)水平。结果月经改善 方而治疗组明显优于屮药组(P0.01),而与西药组比较，差异无统计学意义(P 0.05)；三组患者Kupperman评分治疗前后比较差异均有统计学意义(P0.01), 治疗组在症状改善方面优于两对照组。治疗后三组患者血清FSH、LH、E2较治 疗前有明显变化(PV0.05),治疗组和西药组差异无统计学意义，但均优于屮药 组有统计学意义。结论补水柔木方结合安宫黃体酮明显改善肾虚肝郁型卵巢早 衰患者的临床症状，月经情况及血清生殖激素水平，具有较好的临床效果。 关键词 补水柔木方；安宫黄体酮；卵巢早衰；肾虚肝郁型 Clinical Observation on Treatment of Premature Ovarian Failure of KidneyDeficiency and Liver Stagnation with Combination of Bushuiroumu Recipe andProgesterone Abstract Objective To investigate the effect of Bushuiroumu recipe combined with Medroxyprogesterone Acetate, single Chinese or western medicine on Premature Ovarian Failure(POF). Methods 90 patients with POF caused by kidney deficiency with liver stagnation and randomly divided into three groups, 30 cases each? The treatment group was treated by Bushuiroumu recipe and Medroxyprogesterone Acetate, western medical comparison group was treated by artificial period method, and Chinese medical comparison group was treated by Bushuiroumu recipe. Menstrual improvement and symptoms were observed and the changes of serum reproductive hormone including Serum follicle-stimulating hormone(FSH)and luteinizing hormonc(LH) and cstradiol(E2) before and after treatment were observed. Results Compared with the Chinese medical comparison group, the menstrual improvement of the treatment group is better (P 0.01)? However, compared with the western medical comparison group, the difference (P0.05 ) has no statistical significance.The integral changes of clinical symptoms: According to Kupperman score standard, compared each symptom score of three groups patients pre- and posttreatment, the difference (PVO.Ol)has statistical significance, the efficacy of the treatment group in improving the clinical