中医动静结合理论与应力刺激成骨细胞增殖分化调控机制的相关性探讨.pdf

·8· Chinese Journal of Information on TCM Sep.2017 Vol.24 No.9 中医“动静结合”理论与应力刺激成骨细胞增殖分化 调控机制的相关性探讨 1，2 1，3 1 1 1 赵文韬 ，张晓刚 ，赵希云 ，仝尊 ，王志鹏 1.甘肃中医药大学，甘肃 兰州 730000 ；2.云南中医学院，云南 昆明 650500 ； 3.甘肃中医药大学附属医院，甘肃 兰州 730000 摘要：“动静结合”理论与成骨细胞应力下产生效应的现象相吻合，而近年来关于动静结合治疗的分子生 物学研究文献不多。“动静结合”理论治疗骨折等骨科疾患的方法是利用骨折局部产生的应力，该应力通过影 响成骨细胞的增殖分化而控制骨形成的结果，且已得到相关实验的佐证。本文就此探寻了中医“动静结合”理 论与应力刺激成骨细胞增殖分化相关性的分子生物学依据。 关键词：中医；动静结合；成骨细胞 DOI：10.3969/j.issn.1005-5304.2017.09.003 中图分类号：R274.9 文献标识码：A 文章编号：1005-5304(2017)09-0008-03 Correlation Discussion on TCM Theory of “Static and Dynamic Combination” and Mechanism of Osteoblast Proliferation and Differentiation by Stress Stimulation 1,2 1,3 1 1 1 ZHAO Wen-tao , ZHANG Xiao-gang , ZHAO Xi-yun , TONG Zun , WANG Zhi-peng (1. Gansu University of Chinese Medicine, Lanzhou 730000, China; 2. Yunnan University of Traditional Chinese Medicine, Kunming 650500, China; 3. Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China) Abstract: The theory of “static and dynamic combination” coincides with the effect of osteoblast stress, although there are few articles on molecular biology about the theory in recent years. The treatment of “static and dynamic combination” theory for fractures and other orthopedic disorders is to use the localized stress fracture, and the stress controls bone formation results through afffecting proliferation of osteoblast differentiation, which has proved by relevant experimental evidence. This article discussed the molecular biology basis about the correlation between theory of “static and dynamic co