载药脂肪乳剂的研究进展-天津中草药杂志社.PDF

现代药物与临床 Drugs Clinic 第 26 卷 第 5 期 2011 年 9 月 • 339 • 载药脂肪乳剂的研究进展 1 2, 3 2, 3 2, 3 逯 荻 ，任晓文 ，王 博 ，李洪起 1. 河南大学 药学院，河南 开封 475000 2. 天津药物研究院 制剂技术及研究中心，天津 300193 3. 天津药物研究院 释药技术与药代动力学国家重点实验室，天津 300193 摘 要：脂肪乳作为一种给药载体，不论处方组成还是制备工艺已经日益成熟。SolEmul 技术给油水均难溶药物的制剂带来 希望；自乳化给药系统可提高难溶性药物的生物利用度；阳离子脂肪乳不仅延长药物体内循环时间，还使肺部给药技术得到 长足发展；同时脂肪乳在细胞靶向和中药制剂的研究中也呈现出独特的优势。随着载药脂肪乳各项研究的深入和发展，未来 应用范围必将更加广泛。 关键词：载药脂肪乳；乳化剂；制备方法；脂肪乳剂 中图分类号：R944 文献标志码：A 文章编号：1674 - 5515(2011)05 - 0339 - 05 Recent development of drug-loaded lipid emulsions 1 2,3 2,3 2,3 LU Di , REN Xiao-wen , WANG Bo , LI Hong-qi 1. College of Pharmacy, Henan University, Kaifeng 475000, China; 2. Centre for Pharmaceutical Preparations Technology Research, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China 3. State Key Laboratory of Drug Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China Abstract: As a drug carrier, lipid emulsion has become increasingly mature regardless the prescription composition or preparation methods. SolEmul technology brings hope to insoluble drugs in oil and water; self-emulsifying drug delivery system can improve the bioavailability of the insoluble drugs; cationic lipid emulsion not only extends the drug circulation time, but also greatly develops the pulmonary drug delivery technology; while lipid emulsion has also shown a distinct advantage in cell targeting studies and Chinese medicine formulations. As the drug-loaded lipid emulsion is in-depth study and development, the future will be having more wide range of applications. Key word: drug-loaded lipid emulsion; emulsifier; preparation methods; lipid emulsions 脂肪在医药行业的应用已有数个世纪，15 世纪 药物的毒性和不良反应，增加药物疗效，并具有良 时人们就尝试通过皮下或静脉注射橄榄油的方式提