多发性硬化的磁共振扩散张量成像DTI研究-影像医学与核医学专业论文.docxVIP

汕头大 汕头大学医学院专业学位硕士研究生毕业论文 I I 目 录 目录······························································Ⅰ 中文摘要··························································Ⅱ 英文摘要··························································Ⅲ 英文缩略语························································IV 论文正文·························································（1） 前言··························································（1） 第一部分······················································（6） 材料与方法····················································（6） 结果··························································（8） 讨论·························································（11） 结论·························································（12） 第二部分·····················································（14） 材料与方法···················································（14） 结果·························································（15） 讨论·························································（19） 结论·························································（22） 附图·························································（23） 参考文献·····················································（27） 发表论文························································（31） 文献综述·····················································（31） 致谢····························································（43） 个人简历························································（44） II II 中文摘要 目的：应用扩散张量成像（diffusion tensor imaging，DTI）技术对多发性硬化 （multiple sclerosis ,MS）患者丘脑、尾状核、病灶及正常表现脑白质（NAWM） 进行定量研究，探讨其微观病理改变；通过扩散张量纤维束成像（diffusion tensor tractography,DTT）研究多发性硬化白质病灶局部神经纤维异常。 材料和方法：对13名临床确诊为MS的患者（MS组）及11名年龄及性别匹配的健 康志愿者（对照组）进行DTI检查，分别测量两组受试者的两侧丘脑、尾状核及 NAWM的各向异性分数(FA)、平均扩散率(MD)、轴向扩散率（AD）。比较MS 组与对照组丘脑、尾状核及NAWM的FA、MD、AD值的统计学差异；比较受试 者个体的丘脑与尾状核FA、MD、AD值的统计学差异。测量MS组病灶及脑梗死 组（7例）脑白质病灶的FA、MD值，并比较两组间的统计学差异。 结果：MS组丘脑及尾状核的FA、MD、AD值均大于对照组(P＜0.05),而丘脑的FA 值更为显著（P=0.004）。受试者丘脑（包括MS组与对照组）的FA、MD、AD值 均大于尾状核的相应值，有显著统计学意义(P＜0.001）。MS组胼胝体膝部、内 囊前肢及额叶