不同示踪剂PET-CT在前列腺癌诊断中应用医学培训课件.ppt

Which metabolic?imaging, besides?bone?scan?with 99mTc-phosphonates, for detecting and evaluating?bone metastases in?prostatic?cancer?patients? An open discussion. Q J Nucl Med Mol Imaging. 2015 , 59(4):381-399. Radioimmunoimaging, RII Fusion imaging of 111In-PSA MoAb SPECT RII with MRI 检出：前列 腺癌原发灶 及精囊转移 精囊转移 精囊转移 前列腺癌原发病灶 核医学未来—PET及核素诊治 SNMMI image of the year -- theranostic drug unites imaging and therapy for prostate cancer PET image shows prostate cancer patients successful response to PSMA-617 endoradiotherapy 德国海德堡大学医院和德国癌症研究中心 68Ga-PSMA-617 Choline FDG PSMA Acetate FDHT NaF PCa precision medicine 99mTc-MDP 、PSA 单抗、?18F-FLT、18F-FMAU、anti-18F-FACBC 、18F-FMISO 预祝研讨班 圆满成功！ * * Fig. 3 A 61-year-old patient with PCa treated in March 2009 with RP + pelvic lymph node dissection (GS 4 + 4, pT3N0Mx with initial PSA 8 ng/ mL, PSA nadir after therapy 0.2 ng/mL). No adjuvant ADT was administrated. BCR occurred 19 months after RP. PSA at the time of the investigation was 5.2 ng/mL. 11C-Choline PET/CT images show focal intense uptake in the sixth hepatic segment. An ultrasound-guided biopsy was subsequently performed to confirm the presence of a metastatic lesion from PCa. a MIP image (arrow SUVmax 19.0); b PET, CT and fused images of the hepatic lesion * Fig. 4 A63-year-old patient with PCa treated in 2012 with RP + pelvic LN dissection (GS 5 + 4, T3N1Mx;,initial PSA 12 ng/mL). BCR occurred 12 months after RP. The patients was referred for ADT. Despite ADT during the previous 3 months, PSA increased to 1.9 ng/mL. The patient was referred for restaging with 11C-choline PET/CT. 11C-Choline PET/CT images show two osteolytic lesions with intense tracer uptake in L2 and in C3. a MIP image (dotted arrow L2 uptake, SUVmax 4.3; solid arrow C3 uptake, SUVmax 11.0); b PET, CT and fused images of the lesion in L2; c PET, CT and fused images of the lesion in L2 * A 68-year-old man with prostate cancer treated by radical prostatectomy (pT3aN0Mx, Gleason score 10; positive mar