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* * * * * * * * * * * * P. Di Martino A R. Agniel A K. David A C. TemplerJ. L. Gaillard A P. Denys A H. BottoPublished online: 6 January 2006 Springer-Verlag 2006 Reduction of Escherichia coli adherence to uroepithelial bladder cellsafter consumption of cranberry juice 文獻查證 相關研究(六) （一） Abstract To determine the efficacy of the consumption of cranberry juice versus placebo with regard to the presence of in vitro bacterial anti-adherence activity in the urine of healthy volunteers Participants Twenty healthy volunteers, 10 men and 10 women, were included Design The study was a double-blind, randomized, placebo-controlled, and cross-over study. with a washout period of at least 6 days between every change in regimen AHCPR文獻等級 ：1a （二）INTRODUCTION ZafririD,ofek I,Pocino M,Sharon N(1989)inhibitory activity of cranberry juice on adherence of type 1and type p fimbriated E coli to eukaryotic cells E Coli adherence : type 1 and type p fimbriae cranberry juice constituents proanthocyanidins(cranberry juice )-type p fructose(many fruit juice ) -type 1 (三)成份比較 Cranberry juice Placebo Calories (Kcal) 41.6 42.7 Total carbohydrates (g) 10.4 10.7 Ascorbic acid (mg) 63 63 Total organic acids (g) 1.8 1.6 Total phenolics (mg) 179 161 Total anthocyanidins (mg) 9.3 42 Proanthocyanidins (mg) 40 ND (四)Result Anti-adherence activity of the cranberry juice: comparisonof the regimens, means for the 20 volunteers and 6 types of E coli strains Regimens Decrease in bacterial adherence(%) 250 ml placebo +500 ml mineral water ---- 750 ml placebo 12 250 ml cranberry +500 ml mineral water 45 750 ml cranberry 65 (四)Result No significant differences in the pH or specific gravity between the urine samples collected after cranberry or placebo consumption. We observed a dose dependent significant decrease in bacterial adherence associated with cranberry consumption. Reduction of bacteriuria and pyuria after ingestion of