theDIADstudy-埼玉医科大学总合医疗センター内分泌糖尿病内科.PPTVIP

* * * Figure 1. Effects of DCCT Treatment Group, Severe Hypoglycemia, and Glycated Hemoglobin on Changes in Cognition, from Entry into DCCT to Year 12 in the EDIC Study. The bars show the changes within cognitive domains between cognitive testing at baseline in DCCT and follow-up testing (a mean of 18 years after baseline) expressed as changes in z scores for intensive versus conventional treatment (Panel A), frequency of episodes of severe hypoglycemia (coma or seizure) (Panel B), and mean glycated hemoglobin values (Panel C). Across the three groups, higher levels of glycated hemoglobin were associated with moderate declines in psychomotor efficiency (P0.001) and motor speed (P=0.001), but no other cognitive domain was affected significantly. Cognitive domains are numbered as follows: 1, problem solving; 2, learning; 3, immediate memory; 4, delayed recall; 5, spatial information; 6, attention; 7, psychomotor efficiency; and 8, motor speed. * * * * Cox Regression 打ち切り症例を含む生存データについて、従属変数に事象発生までの時間を使用する有用な回帰モデルが1972年David Coxによって紹介され、比例ハザードモデルあるいはCoxのモデルと呼ばれている。 Copyright restrictions may apply. Whitmer, R. A. et al. JAMA 2009;301:1565-1572. Population Characteristics by Hospital or Emergency Department-Associated Hypoglycemia Copyright restrictions may apply. Whitmer, R. A. et al. JAMA 2009;301:1565-1572. Frequency of Hypoglycemic Episodes by Dementia Status Copyright restrictions may apply. Whitmer, R. A. et al. JAMA 2009;301:1565-1572. Hypoglycemia and Risk of Incident Dementiaa Copyright restrictions may apply. Whitmer, R. A. et al. JAMA 2009;301:1565-1572. Subgroup Analyses of Hypoglycemia and Dementia Riska At least 1 episode of hypoglycemia was diagnosed in 1465 patients (8.8%) and dementia was diagnosed in 1822 patients (11%) during follow-up; 250 patients had both dementia and at least 1 episode of hypoglycemia (16.95%). Compared with patients with no hypoglycemia, patients with single or multiple episodes had a graded increase in risk with fully adjusted ha