2型糖尿病患者氧化应激与动脉粥样硬化相关性分析.docVIP

2型糖尿病患者氧化应激与动脉粥样硬化相关性分析 　　【摘 要】目的：氧化应激引起胰岛β细胞损伤是糖尿病发生、发展的重要机制，本研究旨在观察氧化应激指标与动脉粥样硬化指标的相关性，阐明控制氧化应激的重要性。方法：收集60例正常体检者及92例2型糖尿病患者空腹血清，测定其空腹血糖（FBG）、糖化血红蛋白（HbA1c）、超氧化物歧化酶（SOD）、丙二醛（MDA）、8-异前列腺素F2α（8-iso-PGF2α），并检查糖尿病患者有无颈动脉斑块形成。结果：1、正常人群与糖尿病患者FBG、HbA1c、氧化应激指标之间存在显著性差异；2、FBG、HbA1c与SOD成负相关，与MDA、8-iso-PGF2α呈正相关；3、无颈动脉斑块与有颈动脉斑块糖尿病患者氧化应激指标存在显著差异，且颈动脉内膜中层厚度（IMT）与SOD成负相关，与MDA、8-iso-PGF2α呈正相关。结论：糖尿病患者存在明显氧化应激，氧化应激与动脉粥样硬化显著相关，减少氧化应激有助于控制动脉粥样硬化的发展。 　　【关键词】糖尿病；氧化应激；动脉粥样硬化 　　【中图分类号】R58 【文献标识码】A 【文章编号】1004―7484（2013）09―0636―02 　　The correlation analysis of oxidative stress and atherosclerosis about patients with type 2 diabetes mellitus 　　HUANG Huan，WANG Yao，LEI Hai，LU Peng，ZHANG Li-juan. Pukou Hospital， Nanjing 210031，CHINA 　　【Abstract】Objectives： Pancreas islet β-cell injury induced by oxidative stress is an important mechanism and the development of diabetes mellitus， this study was to observe the correlation between indicators of oxidative stress and indicators of atherosclerosis， to clarify the importance of controlling oxidative stress. Methods： Gather empty stomach serum of 60 people with normal physical examination and 92 patients with type 2 diabetes mellitus， determining fasting serum glucose （FBG）， glycated hemoglobin（HbA1c）， superoxide dismutase（SOD）， malondialdehyde（MDA），8-iso-prostaglandin F2α （8-iso-PGF2α）， and check for diabetes patients with or without carotid artery plaque formation. Results：1.FBG，HbA1c，oxidative stress indicators were significantly different between diabetic patients and normal people；2.FBG， HbA1c was negatively correlated with SOD and MDA， 8-iso-PGF2α positively correlated；3.Without carotid plaque and carotid plaques oxidative stress indicators were significantly different in diabetic patients， and intra-tunica media thickness （IMT） was negatively correlated with SOD and MDA， 8-iso-PGF2α positively correlated. Conclusions： Diabetic patients exist obvious oxidative stress， oxidative stress was significantly associated with atherosclerosis， reduce o