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The Cenral Dogma of Molecular Biology Land of Mayo分子生物学的中心教条地梅奥
The Central Dogma of Molecular Biology Mark Mayo Cypress College The Central Dogma of Molecular Biology Importance of Proteins There are three main kinds: structural - make up most body parts hormone - chemical that controls the body enzyme - catalyst - speeds up chemical reactions Importance of Proteins Without proteins there would be no life All cells make proteins Proteins in your body make up your: Hair Nails Muscles Skin Cartilage Discovery of DNA (deoxyribonucleic acid) 1953 Watson, Crick and Wilkins determined the structure of DNA to be a double helix They won a Nobel Prize for their work Structure of the DNA molecule DNA is shaped like a double helix It is like a spiral staircase Another way to think of it is a twisted ladder Connecting the DNA molecule Rails* of the DNA ladder are alternating sugar phosphates Rungs* are composed of pairs of bases A bonds with T* G bonds with C* Connecting the DNA Molecule The DNA Ladder* Connecting the DNA molecule The two strands of DNA are different One is called the sense strand and it is the plan to make a protein The other strand is the antisense strand and it is only used for protection of the sense strand Connecting the DNA molecule The two strands of DNA are said to be antiparallel* One strand is oriented in a 5’ to 3’ direction* The other strand is oriented in the opposite 3’ to 5’ direction* Connecting the DNA molecule Nucleotides are units composed of abase, phosphate and a sugar Connecting the DNA molecule The two strands of DNA bases are connected by weak forces called hydrogen bonds* Components of DNA Phosphate Components of DNA Deoxyribose (sugar) Components of DNA DNA bases (4 different types) Adenine Thymine* Guanine Cytosine Components of DNA Proteins are attached to the DNA helix in cells These proteins are known as histones They assist in DNA storage DNA and RNA Compared DNA Found only in nucleus* Double stranded helix Bases = ATGC* Sugar = Deoxyribose RNA Found in ribosomes, nucle
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