sVCAM1在娠期肝内胆汁淤积症患者血清中的表达.docVIP

医学论文免费下载sVCAM-1在妊娠期肝内胆汁淤积症患者血清中的表达　　作者：方彩云,方艳梅, 郭立丽 作者单位：郧阳医学院附属太和医院妇产科，湖北 十堰 442000　　【摘要】 目的:探讨可溶性血管细胞粘附分子1(soluble vascular cell adhesion molecule-l, sVCAM-1)在妊娠肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy, ICP)发病中的作用。方法： 酶联免疫吸附法(ELISA)测定49例孕妇血清中sVCAM-1水平。结果： 重型ICP组血清中sVCAM-1水平显著高于正常妊娠组(P0.01)， ICP组随着病情的加重该指标升高，差异有统计学意义(P0.01); 产后该项指标下降与正常妊娠组无显著性差异(P0.05);sVCAM-1的升高与胆汁酸(TBA)、血清丙氨酸氨基转移酶(ALT)、血清天冬氨酸氨基转移酶(AST)呈正相关(P0.01，P0.05)。 结论：粘附分子的异常表达可能是ICP发病机制的一个重要环节。　　【关键词】 妊娠肝内胆汁淤积症; 血管细胞粘附分子1　　Expressina of Soluble Vascular Cell Adhesion Molecule-l in the Pathogenesis of Intrahepatic Cholestasis of Pregnancy　　FANG Cai-yun, FANG Yan-mei, GUO Li-li　　(Department of Gynaecology and Obstetrics, Taihe Hospital, Yunyang Medical College, Shiyan,Hubei 44200，China)　　Abstract：Objective To investigate the role of serum soluble vascular cell adhesion molecule-l( sVCAM-1) in the pathogenesis of intrahepatic cholestasis of pregnancy(ICP). Methods The serum sVCAM-1 levels were determined in 49 by ELISA. Results The level of serum sVCAM-1 was significantly elevated in women with mild and severe ICP compared with control subjects(P0.01), and it markedly decreased 5 days after delivery, with no significant difference compared with control subjects(P0.05). The levels of sVCAM-1 from women with ICP had a significant positive correlation with total bile acid(TBA), alanine aminotransferase(ALT) and aspartate aminotransferase(AST)(P0.01 and P0.05,respectively). Conclusion The abnormal expression of adlesion molecule may play an important role in the pathogenesis of ICP.　　Key words： Intrahepatic cholestasis of pregnancy(ICP); Soluble vascular cell adhesion molecule-l　　妊娠肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)是发生于妊娠中晚期，以皮肤瘙痒、黄疸、胆汁酸(TBA)、血清丙氨酸氨基转移酶(ALT)、血清天冬氨酸氨基转移酶(AST)轻到中度升高，产后症状迅速消失为特征的妊娠期并发症，因易引起胎儿窘迫、早产、死胎、死产而被列为高危妊娠之一。其病因目前仍不明确。最近国内外大量研究表明，ICP的发生与免疫功能的改变有关[1]。可溶性血管细胞粘附分子1(soluble vascular cell adhesion molecule-l,sVCAM-1)的含量改变是抗免疫反应的结果。本研究通过测定ICP患者血清中可溶性血管细胞粘附分子-1水