Predicting subsquent significant hyperbilirubinemia in healthy term 在随后的显着预测健康足月高胆红素血症.docVIP

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Predicting subsquent significant hyperbilirubinemia in healthy term 在随后的显着预测健康足月高胆红素血症.doc

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Predicting subsquent significant hyperbilirubinemia in healthy term 在随后的显着预测健康足月高胆红素血症

Model to Predict Hyperbilirubinemia in Healthy Term and Near-Term Newborns with Exclusive Breast Feeding Hsin-Chung Huang1,2, Hwai-I Yang3,4, Yu-Hsun Chang5, Rui-Jane Chang5, Mei-Huei Chen6, Chien-Yi Chen1, Hung-Chieh Chou1, Wu-Shiun Hsieh1, Po-Nien Tsao1 1Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan 2Department of Pediatrics, Taipei City Hospital, Heping FuYou Branch, Taipei, Taiwan 3Molecular and Genomic Epidemiology Center, China Medical University Hospital, Taichung, Taiwan 4Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan 5Departemtn of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan 6Department of Pediatrics, Cardinal Tien Hospital Yung Ho Branch, Taiwan Running title Model to predict significant neonatal hyperbilirubinemia Correspondence to: Dr. Po-Nien Tsao 1Departments of Pediatrics National Taiwan University Hospital, Taipei, Taiwan 8 Chung-Shan South Road, Taipei 10002, Taiwan Email: tsaopn@ntu.edu.tw Tel: 886-2ext 71551 Fax: 886-2 Abstract Background: The aim of this study was to identify the high risk newborns who will subsequently develop significant hyperbilirubinemia during 4th to 10th days of life by using the clinical data from the first 3 days of life. Methods: We retrospectively collected exclusively breast-feeding healthy term and near-term newborns born in our nursery between May 1 2002 to June 30 2005. Clinical data, including serum bilirubin were collected and the significant predictors were identified. Bilirubin level≧15mg/dL during 4th to 10th days of life was defined as significant hyperbilirubinemia. A prediction model to predict subsequent hyperbilirubinemia was established. This model was externally validated in another group of newborns who enrolled by the same criteria to test its discrimination capability. Results: Totally, 1979 neonates were collected and 1208 cases were excluded by our exclusion criteria. Finally, 771 newb