种植体表面活性肽蛋白修饰研究进展.docVIP

种植体表面活性肽蛋白修饰研究进展 　　[摘要]种植义齿因其舒适美观、咀嚼功能恢复良好以及能够避免或减少天然牙的磨除，越来越多地应用于临床。钛基种植体与周围组织形成良好的骨性愈合即骨整合是种植义齿临床成功的关键。尽快达到良好的骨整合，对于实现种植体的早期负载甚至即刻负载和长期稳定十分重要。种植体表面生物化学修饰改性是提高骨整合的重要途径，各种活性肽/蛋白因其确切的成骨效果，近年来一直是国内外材料专家种植体表面修饰的研究热点。本文就种植体表面活性肽/蛋白修饰的研究进展作一综述。 　　[关键词]种植体；活性肽/蛋白；改性；骨整合 　　[中图分类号]R 783.1[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.01.021 　　Research progress on implant surface bioactive peptide/proteinCao Xin, Yu Weiqiang, Zhang Fuqiang.（Dept. of Prosthodontics, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China; Shanghai Research Institute of Stomatology, Shanghai 200011, China） 　　[Abstract]Implant denture has been widely used in the clinic due to its features of comfort and beauty. Besides, it brings a good recovery of masticatory function and a successful avoidance or reduction of the natural teeth’s preparation. The fine bone union（osseointegration）formed between the titanium matrix implant and its surrounding tissue is key to the clinical success of implant denture. It is quite important to achieve better osseointegration as early as possible so as to realize the early loading, even immediate loading and long-term stability of the implant. The modification of the implant surface is an important means to improve osseointegration. Various kinds of bioactive peptides/proteins have been the research focus in implant surface modification by the material experts owing to their certain bone growth. A review of the research progress is given in this paper concerning the bioactive peptide/protein modification of the implant surface. 　　[Key words]implant；bioactive peptide/protein；modification；osseointegration 　　经过30多年的临床实践考验，种植义齿已日趋成为成熟的口腔修复治疗手段。目前，钛基金属因其良好的生物相容性、机械强度和抗腐蚀性能等优点，是种植体最常用的基体材料，钛基种植体与周围组织形成良好的骨性愈合即骨整合，是种植义齿临床成功的关键。尽快达到良好的骨整合，对于实现种植体的早期负载甚至即刻负载和长期稳定十分重要。种植体表面修饰改性是提高骨整合的重要途径，主要包括：种植体表面生物陶瓷涂层、种植体表面生物化学改性、种植体表面纳米修饰等。其中，各种活性肽/蛋白因其确切的成骨效果，近年来一直是材料专家们种植体表面修饰的研究热点[1]。本文就种植体表面活性肽/蛋白修饰的研究进展作一综述。 　　1蛋白类 　　釉原蛋白是发育中釉质的主要