短期抗甲状腺药物治疗与抗中性粒细胞胞浆抗体关系研究.docVIP

短期抗甲状腺药物治疗与抗中性粒细胞胞浆抗体关系研究 　　【摘要】 目的 探讨甲状腺功能亢进症（简称甲亢）患者治疗前后抗中性粒细胞胞浆抗体(ANCA)检出情况及其与短期抗甲状腺药物治疗的关系。方法 将60例初诊Graves病甲亢患者治疗前作为未治疗组(n=60)，治疗后归为治疗组(n=10)，40例非甲亢健康人群作为对照组(n=40)。用间接免疫荧光法(IIF)检测血清ANCA及抗核抗体(ANA)。结果 2例初诊未治疗甲亢患者ANCA-IIF阳性，10例治疗前ANCA阴性患者药物治疗6个月后及健康人群未检测出ANCA，患者与健康人群差异无统计学意义(P0．05)。所有血清ANA均阴性。结论 ANCA与Craves病本身可能无关，以及短期抗甲状腺药物治疗可能不诱发ANCA。? 　　【关键词】甲状腺功能亢进症；抗体，抗核；甲状腺拮抗药 　　 　　The preliminary study on relation between short-term treatment by anti-thyroid drug and against neutrophil cytoplasmic antigens 　　 　　XU Hua,CHI Lian-xiang,WEN Xing-zhu,et al.Department of the Fhird Surgery the People?s Hospital of Bao’an Shenzhen,ShenzhenGuangdong Provicne 518101,China 　　? 　　【Abstract】 Objective To investigate the detection of Against Neutrophil Cytoplasmic Antigens(ANCA)before and after treatment in patients with hyperthyroidism,and the relation with short-term treatment by anti-thyroid drug.Methods 60 cases with graves disease before treatment was untreated group(n=60),after treating by anti-thyroid drug these 10 cases would be as treatment group(n=10),40 healthy people served as control group(n=40).ANCA and ANA(Antinuclear Antibody)were detected by indirect immunofluorescence(IIF)experiments.Results 2 cases with graves disease who were newly diagnosed were ANCA-IIF(+).ANCA had not be detected in both 40 healthy people and the 10 cases who were ANCA-IIF(-)before treating by anti-thyroid drug for 6 months.ANA had not be detected in these 3 groups.Conclusion ANCA may irrelevant with graves disease,and short-term treatment by anti-thyroid drug may not induce ANCA.? 　　【Key words】 　　Hyperthyroidism;Antibody;Antinuclear;Thyroid antagonists 　　 　　【摘要】 目的 探讨甲状腺功能亢进症（简称甲亢）患者治疗前后抗中性粒细胞胞浆抗体(ANCA)检出情况及其与短期抗甲状腺药物治疗的关系。方法 将60例初诊Graves病甲亢患者治疗前作为未治疗组(n=60)，治疗后归为治疗组(n=10)，40例非甲亢健康人群作为对照组(n=40)。用间接免疫荧光法(IIF)检测血清ANCA及抗核抗体(ANA)。结果 2例初诊未治疗甲亢患者ANCA-IIF阳性，10例治疗前ANCA阴性患者药物治疗6个月后及健康人群未检测出ANCA，患者与健康人群差异无统计学意义(P0．05)。所有血清ANA均阴性。结论 ANCA与Craves病本身可能无关，以及短期抗甲状腺药物治疗可能不诱发ANCA。? 　　【关键词】甲状腺功能亢进症；抗体，抗