器官移植的发展与未来【精品-ppt】.pptVIP

器官移植的發展與未來 台北榮總 一般外科 龍藉泉 Myth and Legend Myth and Legend Myth and Legend MAIN STEPS IN GRAFT HISTORY THE PLANT GRAFT: VERY EARLY IN MAN’S HISTORY THE ANIMAL GRAFT: 18TH CENTRURY THE HUMAN GRAFT: 18TH CENTURY ORGAN TRANSPLANTATION: 20TH CENTURY FROM GARDEN TO FARMYARD FROM GARDEN TO FARMYARD 19TH CENTURY: ALL FROMS OF GRAFTS THE FIRST TRANSPLANTATION IN ANIMAL At the Vienna Medical Society meeting held in January 1902, the surgeon Emerich Ullmann reported the first case of renal transplantation performed in the neck of a dog. The ureter, brought out to the skin , oozed a “ liquid which resemble urine” over a period of five days. Dr. Alexis Carrel – A magician First renal transplantations in man : 1906-1913 In 1906, Mathieu Jaboulay performed renal transplantation in man. He transplanted the left kidney of a pig, killed 3 hours previously, into the left elbow of a woman suffering from nephrotic syndrome. The graft removed on the third day and the vessels were found to be obstructed by clots.. First transplantation between humans : 1933 In 1933, the russian surgeon Voronoy (1896-1961) performed the first homologous renal transplantation in man using a human cadaver kidney. The Brigham commando : 1947 A young woman was in profound coma with anuria for 10 days following an abortion complicated by acute tubulopathy due to septic shock and incompatible transfusion. Paris, Christmas 1952 : the present from a mother to her son A real Success : 1954 MAJOR HISTOCOMPATIBILITY COMPLEX : 1952 Immunosuppression : Total Body Irradiation First prolonged survival of renal transplantation with an unrelated donor Development of Immunosuppressive Drugs Advent of Cyclosporine Progress in Hemodialysis William J. Kolff, father of the artificial kidney and heart. The first artificial kidney designed by Kolff in 1945. Tissue Typing Organ Preservation Organ Preservation Liver Transplantation Pancreas and Intestinal Transplantation Heart and Lung Transplantation Artificial Heart Heart