一种复方芳香精油的镇静催眠功效及应用分析-sedative and hypnotic effects and application analysis of a compound aromatic essential oil.docxVIP

一种复方芳香精油的镇静催眠功效及应用分析-sedative and hypnotic effects and application analysis of a compound aromatic essential oil.docx

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一种复方芳香精油的镇静催眠功效及应用分析-sedative and hypnotic effects and application analysis of a compound aromatic essential oil

SEDATIVEHYPNOTICEFFICACYOFTHEBLENDEDESSENTIALOILANDITSAPPLICATIONRESEARCHABSTRACTInthepaper,chemicalcompositionanalysis,olfactorypreferencetesting,sedative-hypnoticefficacytestingandpreparationofmicrocapsulehasbeenconductedforakindofessentialoilblendedbysweetmarjoramoil,germanchamomileoil,andlavenderoil.Themainconclusionsareasfollows:AccordingtoGC/MS,terpene-basedsubstanceisthemaincomponentsoftheblendedessentialoil,followedbylinalool(10.02%)andlinalylacetate(7.97%).Theresultsofolfactorypreferencetestinginmiceshows,theblendedoilhighlydilutedareattractivescentsandthescentswithoutdilutedareaversive.Accordingtospontaneouslocomotoractivity,duringtheprocessofscent-inhaling,theinactivetimeofmicewasextraordinaryincreasedwithdilutedscent,especiallytheconcentrationof10-3and10-4,by96%and120%respectively.Accordingtopentobarbitalsodium-inducedsleeptest,thesleeplatencyofmicewasshortenedby32%and42%,whilethesleeptimewasextraordinaryprolongedby74%and70%,withthescentof10-3and10-4respectively.Theblendedessentialoilwasencapsulatedbyβ-cyclodextrin(β-CD),theoptimalparametersweredeterminedbyorthogonalexperiments,andshowedasfollows:ratioofcoreandwallmaterial1:8(w/w),concentrationofβ-CD12%(w/w),reactiontemperature50℃,reactiontime1h.Yieldofmicrocapsulewas83.54%,andtheencapsulationefficiencywas69.42%undertheoptimalconditions.KEYWORDS:blendedessentialoil,olfactorypreference,sedariveandhypnotic,microcapsule,β-cyclodextrin目录第一章综述.............................................................................................................................................11.1芳香植物........................................................................................................................................11.1.1甜牛至.....................................................................................................................................21.1.2德国甘菊.................................................................................................................................31.1.3薰衣草..

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