血清vegf与tsgf检测诊断原发性肝癌及判定tace疗效的价值-the value of serum vegf and tsgf in the diagnosis of primary liver cancer and the evaluation of tace efficacy.docxVIP

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血清vegf与tsgf检测诊断原发性肝癌及判定tace疗效的价值-the value of serum vegf and tsgf in the diagnosis of primary liver cancer and the evaluation of tace efficacy.docx

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血清vegf与tsgf检测诊断原发性肝癌及判定tace疗效的价值-the value of serum vegf and tsgf in the diagnosis of primary liver cancer and the evaluation of tace efficacy

ABSTRACTBackground:A fetoprotein (AFP), as a kind of specific serological protein markers has played an important role in the diagnosis of primary hepatocellular carcinoma (PHC)and the eurative effect and evaluation after surgery, Interventional therapy. The specific degree AFP in the diagnosis of PHC is high, however, its sensitivity is lower, and AFP cant be used to judge therapeutic effect objectively in preoperative patients with AFP negative.So find other sensitive and specific serological markers for the diagnosis of PHC and evaluation of its curative effect has important clinical practical value.Objectives：Through the determination of serum VEGF and TSGF expression level in benign and malignant liver disease, its diagnostic value in different benign and malignant liver disease, further explore joint detection of VEGF and TSGF feasibility and important significance in the diagnosis of PHC.Through the determination of PHC patients serum VEGF and TSGF expression levels before and after the hepatic artery embolism chemotherapy (TACE), to analyze its relationship with interventional treatment and its value for therapeutic intervention and prognosis judgement.Methods：Selection 171 PHC patients cases, 65 cases of patients with liver cirrhosis, 51 cases of patients with hepatitis and healthy physical examination of 56 cases, a total of 343 cases of patients hospitalized in our hospital between January 1, 2014 to December 31,2014.All entrants are through symptoms, signs and routine blood, and clotting function, liver function, AFP and other laboratory examination and epigastric enhancement CT and/or enhanced magnetic resonance imaging (MRI) or B chao deng imaging examination comprehensive evaluation index.Detect the serum VEGF and TSGF expression levels, and the conventional patient has been treated with follow-up.Results:1, PHC patients serum VEGF and TSGF expression levels significantly higher than other group (P 0.05). Serum VEGF and TSGF expression levels of AFP