血清hmgb1及hs-crp水平与糖尿病周围神经病变的相关性研究-correlation between serum hm gb1 and hs - crp levels and diabetic peripheral neuropathy.docxVIP

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血清hmgb1及hs-crp水平与糖尿病周围神经病变的相关性研究-correlation between serum hm gb1 and hs - crp levels and diabetic peripheral neuropathy.docx

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血清hmgb1及hs-crp水平与糖尿病周围神经病变的相关性研究-correlation between serum hm gb1 and hs - crp levels and diabetic peripheral neuropathy

目录中文摘要 ······························································································· (1）英文摘要 ······························································································· (2）论文题目 ······························································································· (4）材料与方法 ···························································································· (5) 结果·····································································································(11) 讨论·····································································································(14) 结论·····································································································(21) 参考文献 ······························································································(21) 文献综述 ······························································································(25) 参考文献 ······························································································(36) 缩略语表 ······························································································(42) 攻读学位期间发表文章情况 ······································································(43) 个人简历 ······························································································(44)致谢···································································································· (45)内蒙古医科大学硕士研究生学位论文（2 0 12 ）1中文摘要目的探讨健康人群、单纯 2 型糖尿病(T2DM)、2 型糖尿病合并周围神经病变(DPN) 患者血清中高迁移率族蛋白 B1（HMGB1）及超敏 C-反应蛋白（hs-CRP）不同浓度水平的测定，以其研究 HMGB1 和 hs-CRP 两种蛋白与 2 型糖尿病及其糖尿病合并周围神经病变的相关性和相互影响因素，从而进一步探讨血清 HMGB1 和 hs-CRP 蛋白在 2 型糖尿病及其糖尿病合并周围神经病变的早期发现、早期诊断、早期治疗中的重要价值。方法选取内蒙古医科大学附属人民医院内分泌科 2013 年 12 月至 2014 年 12 月住院的 2 型糖尿病患者 66 例，其中男性 29 例,女性 37 例，年龄在 34-65 岁之间，平均年龄为 49.80±9.24岁。再根据肌电图检测神经传导速度的不同，分为两组：A 组为单纯 2 型糖尿病患者 34例，B 组为 2 型糖尿病合并周围神经病变组患者 32 例。另外经门诊体检选择临床资料完整的健康人群 30 例作为正常对照组（C 组）。检测血清 HMGB1 蛋白的浓度采用酶联免疫吸附反应(ELISA),检测超敏 C-反应蛋白的浓度采用免