新型手性硫脲催化剂的合成及催化性能分析-synthesis and catalytic performance analysis of a new chiral thiourea catalyst.docxVIP

AbstractOver the past decade, organocatalysis has grown rapidly to become one of the most exciting fields in asymmetric catalysis and much interest has been devoted to the development of highly efficient organocatalysts for a variety of reactions.In this dissertation, two novel chiral amine-thiourea catalysts were designed and synthesized from natural product - isosteviol via multi-step reactions.Asymmetric Michael addition of isobutyraldehyde to nitroalkenes were studied by using the chiral amine-thiourea catalyst C1and C2. Thiourea C1 were proven to be more effective. The reaction displayed obvious generality and functional- group tolerance in chloroform with 20 mol% catalyst C1. The corresponding adducts were obtained with good to high yields (57-92%) and high to excellent enantioselectivities (93-98% ee)Key words: asymmetric organocatalysis, chiral thiourea, Michael addition, isostiviolII目录摘要 ............................................................................................................................... IAbstract......................................................................................................................... II目录 .............................................................................................................................III第一章 前言 .................................................................................................................11.1 硫脲类催化剂的研究进展 ............................................................................11.1.1 手性硫脲催化的不对称 Michael 加成反应11.1.2 手性硫脲催化的不对称 Mannich 反应31.1.3 手性硫脲催化的不对称 Aldol 反应51.1.4 手性硫脲催化的不对称 MBH 反应61.1.5 手性硫脲催化的不对称环加成反应 .................................................61.1.6 手性硫脲催化的不对称 F-C 烷基化反应71.1.7 手性硫脲催化的不对称串联反应 .....................................................81.2 异斯特维醇衍生物作为催化剂的研究进展 ................................................91.2.1 异斯特维醇-脯氨酸缀合物的合成及应用 ........................................91.2.2 异斯特维醇-硫脲的合成及应用 ...................................