白三烯B4在婴幼儿毛细支气管炎发病中作用.docVIP

白三烯B4在婴幼儿毛细支气管炎发病中作用 　　【摘要】 目的 探讨白三烯B4在婴幼儿毛细支气管炎发病中的作用。方法 采用平衡组设计方案,将符合病例纳入标准的50例临床病例为实验组,正常健康体检的50名婴幼儿为对照组。其中实验组采用治疗前后自身对照,分别于治疗前、后做血清中白三烯B4水平的检测,分别与对照组血清中白三烯B4水平作对比。结果 婴幼儿毛细支气管炎患儿血清中白三烯B4水平治疗前明显高于治疗后,且治疗前、后血清中白三烯B4水平均明显高于对照组。结论 白三烯B4是毛细支气管炎发病中的炎性介质之一。 　　【关键词】白三烯B4;毛细支气管炎;婴幼儿 　　 　　Role of leukotriene B4 in infant bronchiolitis 　　 　　LIANG Yu,LIU Chen-zhou.Paediatrics Department,Nanhai Affiliated Maternity and Children’s Hospital of Guangzhou University of Traditional Chinese Medicine,528200,China 　　 　　【Abstract】 Objective To investigate the role of leukotriene B4 in infant bronchiolitis.Methods Adopting the design plan of balanced set,50 clinical cases according with internalized standard were the experimental group,50 infants of healthy physical examination were the control group.Experimental group adopting own control,concentration of Serum leukotriene B4 in pre-therapy and post-treatment were measured by ELISA respectively and were contrasted with that of the control group.Results Concentration of Serum leukotriene B4 in experimental group in pre-therapy were obviously higher than that in post-treatment,they were obviously higher than that of the control group.Conclusion Leukotriene B4 is one of mediators of inflammation in infant bronchiolitis. 　　【Key words】Leukotriene B4;Bronchiolitis;Infants 　　 　　DOI:10.3760/cma.j.issn 1673-8799.2010.06.22 　　作者单位:528200广州中医药大学附属南海妇产儿童医院/佛山市南海妇幼保健院儿科(梁玉); 广东省江门市中心医院/中山大学附属江门医院儿科(刘郴州) 　　 　　近年来的研究表明毛细支气管炎患儿血清白三烯水平升高,可能是引起毛细支气管炎后反复喘息和哮喘因素之一[1]。不同的病毒种类所致的毛细支气管炎对白三烯的产生影响不大,且毛细支气管炎患儿血清中半胱氨酸白三烯(Cysteine leukotrienes,Cys LTs)水平明显升高,提示Cys LTs在毛细支气管炎发病中有不可忽视的作用[2]。??是对于白三烯B4(leukotriene B4,LTB4)在毛细支气管炎患儿发病中的作用如何,目前很少报道;本文报道通过对治疗前后毛细支气管炎患儿血清中LTB4的检测,以明确LTB4在婴幼儿毛细支气管炎发病中的作用。 　　1 资料与方法 　　1.1 实验组病例入选标准 ①符合《实用儿科学》第七版“毛细支气管炎”的诊断标准的住院患者;②家属签署知情同意书同意者;③依从性好;④年龄在3个月~2岁之间者。 　　1.2 实验组病例排除标准 有下列情况之一者均排除:①有支气管哮喘、过敏性疾病病史、合并特应性皮炎的患者;②依从性不好的患者;③入院前使用过白三烯拮抗剂。 　　1.3 对照组入选标准 ①门诊正常健康体检的婴幼儿;②家属签署知情同意书同意者;③年龄在3个月~2岁之间者。 　　1.4 对照组排除标准 既往有支气