软组织肿瘤 成人软组织肉瘤化疗.pptVIP

Overview Drugs Treatment neoadjuvant chemotherapy adjuvant chemotherapy Advanced or metastatic diseases chmeotherapy targeted therapy Sarcomas constitute a heterogeneous group of rare solid tumors of mesenchymal cell origin with distinct clinical and pathological features Age. Soft tissue sarcomas can occur at any age, but overall are more common in older adults. The average age at diagnosis is 57 years. Certain types of sarcomas are more common in children, however. Chemical exposure. Being exposed to certain chemicals, such as vinyl chloride and dioxin, can increase the risk of soft tissue sarcomas. Radiation exposure. Previous radiation treatment for other cancers can increase the risk of soft tissue sarcomas. a new lump or a lump that is growing anywhere in the body may or may not cause pain may include abdominal swelling or a lump in the abdomen nausea vomiting heartburn abdominal pain blood in vomit or stool Incisional biopsy: The removal of part of a lump or a sample of tissue. Core biopsy: The removal of tissue using a wide needle. Excisional biopsy: The removal of an entire lump or area of tissue that doesn’t look normal. the type of soft tissue sarcoma the stage of the cancer (how far the cancer has progressed) the grade of the tumour (how abnormal the cancer cells look and behave) Single Agents Doxorubicin Ifosfamide Dacarbazine Gemcitabine Paclitaxel Docetaxel Pemetrexed Temozlomide Irinotecan Topotecan Pelyated liposmal doxorubicin Trabectedin The single agent response rates (RR) are in the range of 20 to 30% survival in the range of 7.7 -12 months The best response rates are seen with dosages in the range of 75 mg/m 2 to 90 mg/m 2 Epirubicin is a less cardiotoxic analog of doxorubicin, which failed to demonstrate any benefit as compared to doxorubicin liposomal doxorubicin can be used in patients where doxorubicin is contraindicated, but the response rates of this drug as a single agent are lower than the conventional doxoru