武汉会议报告----余家会.pptVIP

高分子前药的基本模型 纳米高分子前药的肿瘤靶向输运机理 新药创制先进技术研究院 ????????????????????????? East China Normal University * 高分子前药：纳米技术用于癌症诊疗的新策略 华东师范大学 新药创制先进技术研究院 1 2 3 4 Endosome nuclear 研究背景 小分子抗癌药物：高毒、低效、无选择性 高分子前药：低毒、高效、有选择性 高分子前药的纳米尺度组装 100-800 nm 8-400nm 循环系统 肿瘤组织 肿瘤细胞 8 nm 纳米高分子前药的临床研究现状 Cancer Abraxane? Company: American Pharmaceutical Partners, Inc. (USA) Anti-cancer drug used to treat advanced breast cancer “Albumin-bound form of paclitaxel with a mean particle size of approximately 130 nanometers” Approved by the FDA in January 2005 Data Source: oi/label/2005/021660lbl.pdf Doxil? Company: ALZA Corporation (USA) “Anti-cancer drug for the treatment of refractory ovarian cancer and AIDS-related Kaposi’s sarcoma” “First marketed product to incorporate STEALTH? technology” “STEALTH? technology is composed of lipid nanoparticles that incorporate a polyethylene glycol (PEG) coating. This coating helps evade the potential impact of the immune system and enables STEALTH? technology to provide the precise delivery of drugs to disease-specific areas of the body.” Approved by the FDA in February 2005 Emend? Company: Merck Co., Inc. (USA) Anti-nausea drug for chemotherapy patients that contains “80 or 125 mg of aprepitant formulated as NanoCrystal drug particles” “NanoCrystal particles are small particles of drug substance, typically less than 1000 nanometers (nm) in diameter, which are produced by milling the drug substance using a proprietary, wet-milling technique. The NanoCrystal particles of the drug are stabilized against agglomeration by surface adsorption of selected GRAS (Generally Regarded As Safe) stabilizers. The result is an aqueous dispersion of the drug substance that behaves like a solution – a NanoCrystal colloidal dispersion, which can be processed into finished dosage forms for all routes of administration.” Approved by the FDA in March 2003, commercially launched in the United States in April 2003 Immunosuppressant Rapamune? Manufacturer: Wyeth (USA) Immuno