a族链球菌pcdna3.1spy1536真核表达基因疫苗的保护 性研究word格式论文.docxVIP

优秀毕业论文 精品参考文献资料 目 录 中文摘要··········································································································1 英文摘要··········································································································3 英文缩写··········································································································8 研究论文 A 族链球菌 pcDNA3.1/Spy1536 真核表达基因疫苗的保护性研究 前言···········································································································9 材料与方法·····························································································11 结果·········································································································21 附图·········································································································23 附表·········································································································30 讨论·········································································································34 结论·········································································································37 参考文献···································································································38 综述 生脓链球菌和其噬菌体之间的关系···················································44 致谢·················································································································53 个人简历·········································································································54 3 中 文 摘 要  PAGE 7 万方数据 A 族链球菌 pcDNA3.1/Spy1536 真核表达基因疫苗的保护性研究 摘 要 目的：A 族链球菌 (Group A Streptococcus, GAS or Streptococcus pyogenes) 是一种革兰氏阳性菌球菌，又称β乙型溶血性链球菌，能引起 咽炎，还可引起严重感染，如链球菌中毒性休克综合征，败血症，或链球 菌感染后的一些后遗症，如：风湿性心脏病，关节炎，肾小球肾炎。据估 计，每年，GAS 引起的咽炎在 5 亿例以上，脓皮病在 1 亿例以上，而风 湿性心脏病和侵入性感染等严重的 A 族链球菌疾病可导致至少 500000 人 死亡[2]。侵入性 GAS 疾病的死亡率在 15 - 30%之间，但 在链球菌中毒性 休克综合征病例则可超过 50%。 更严重的是，GAS 能引起严重的自身免 疫性疾病，如风湿热，风湿性心脏病，风湿性关节炎，风湿性肾小球肾炎 等严重的后遗症