contributions of neuropsychology and neuroimaging to神经心理学和神经影像学的贡献精品.pdfVIP

CONTRIBUTIONS OF NEUROPSYCHOLOGY AND NEUROIMAGING TO UNDERSTANDING CLINICAL SUBTYPES OF MILD COGNITIVE IMPAIRMENT Amy J. Jak,*,y Katherine J. Bangen,* Christina E. Wierenga,*,y Lisa Delano-Wood,*,y Jody Corey-Bloom,y,z and Mark W. Bondi*,y *Department of Psychiatry, School of Medicine, University of California, San Diego 92093, USA yVeterans Affairs San Diego Healthcare System, San Diego 92161, USA zDepartment of Neurosciences, School of Medicine, University of California, San Diego 92093, USA I. Introduction II. Neuropsychological Presentation III. Stability of Diagnosis IV. Conversion to Dementia V. MCI and Health Variables VI. Daily Functioning and MCI VII. Neuroimaging A. Structural MRI B. Diffusion Tensor Imaging C. Functional MRI VIII. Treatment IX. Conclusions References The original conceptualization of mild cognitive impairment (MCI) was primarily as an amnestic disorder representing an intermediate stage between normal aging and Alzheimer’s dementia (AD). More recently, broader concep- tualizations of MCI have emerged that also encompass cognitive domains other than memory. These characterizations delineate clinical subtypes that commonly include amnestic and non-amnestic forms, and that involve single and multiple cognitive domains. With the advent of these broader classifications, more specific information is emerging regarding the neuropsychological presentation of indivi- duals with MCI, risk for dementia associated with diVerent subtypes of MCI, and neuropathologic substrates connected to the clinical subtypes. This review pro- vides an overview of this burgeoning literature specific to clinical subtypes of MCI. Focus is primarily on neur