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antimicrobial peptides and wound healing biological and therapeutic considerations.抗菌肽和伤口愈合的生物治疗方面的考虑.pdf

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antimicrobial peptides and wound healing biological and therapeutic considerations.抗菌肽和伤口愈合的生物治疗方面的考虑

DOI: 10.1111/exd.12929 Review Article /journal/EXD Antimicrobial peptides and wound healing: biological and therapeutic considerations 1 2 3 Maria Luisa Mangoni , Alison M. McDermott and Michael Zasloff 1Department of Biochemical Sciences ‘A. Rossi Fanelli’, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy; 2The Ocular Surface Institute, College of Optometry, University of Houston, Houston, TX, USA; 3MedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA Correspondence: Maria Luisa Mangoni, Department of Biochemical Sciences ‘A. Rossi Fanelli’, Sapienza University of Rome, Via degli Apuli, 9-00185 Rome, Italy, Tel.: +39-06-4991-7693, Fax: +39-06-4991-7566, e-mail: marialuisa.mangoni@uniroma1.it Abstract: Repair of tissue wounds is a fundamental process to re- the evidence for a role of AMPs as endogenous mediators of wound establish tissue integrity and regular function. Importantly, infection is healing and their promising therapeutic potential for the treatment of a major factor that hinders wound healing. Multicellular organisms non-life-threatening skin and other epithelial injuries. have evolved an arsenal of host-defense molecules, including Key words: antibiotic resistance – antimicrobial peptide – frog skin – antimicrobial peptides (AMPs), aimed at controlling microbial innate immunity – skin infections – wound healing proliferation and at modulating the host’s immune response to a variety of biological or physical insults. In this brief review, we provide