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Ok, here’s the results. Cannot pinpoint individual nutrients with this design. Nutrients that were not targeted for changed differed significantly across dietary patterns. The only conclusions that can be drawn are that adopting a diet that incorporates more fruits and vegetables results in favorable change in blood pressure. Further reductions in blood pressure can be achieved by adopting a diet that also includes more low-fat dairy products and fish and less red meat and fats. There were some unanswered questions following the original DASH study. One of them was “Will moderating sodium intake along with the combination diet have an additive effect?” That was the question that DASH-Sodium sought to answer. The subject population had similar characteristics to those in the first DASH study. Here’s the design. Hopefully you can follow this. Subjects within each diet group served as their own controls with respect to sodium intake. As you can see from this slide, the greatest blood pressure reduction was achieved by going from a typical American diet (control) to the DASH combination diet (far left column). Reducing the sodium level of the DASH combination diet to 2400 mg, and to 1500 mg reduced blood pressure only by another 1.3 mm Hg and 1.7 mm Hg. DASH Reduces Homocysteine Levels Effect a result of diet high in vitamin B-rich milk and milk products, fruits and vegetables Lowering homocysteine with DASH may reduce CVD risk an additional 7%-9% -Appel, et al. Circulation, 102:852, 2000 DASH Reduces Cholesterol Total cholesterol 13.7 mg/dl LDL cholesterol 10.7 mg/dl HDL cholesterol 3.7 mg/dl -Obarzanek, et al, Am J Clin Nutr, 74:80, 2001 Unresolved Issues What are the principal nutrients in foods responsible for the BP-lowering effect of the DASH diet? What is the effect of DASH in free-living individuals selecting their own food? What is the combined effect of simultaneously implementing all known lifestyle interventions that influence BP
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