【体外膜肺ECMO精品课件】 Economic Evaluation Journal Club.pptVIP

Analysis SPR Workshop: Dollars and Sense Cost-Effectiveness Study Cost-Effectiveness = Costs of Treatment A – Costs of Treatment B Effects of Treatment A – Effects of Treatment B ? 2012 Dukhovny, Lorch, Profit, Kamholz, Zupancic Table 2 from Kamholz et al. Archives of disease in childhood Fetal and neonatal edition 2012;97:F93-8 ? 2011 Dukhovny, Lorch, Profit, Kamholz, Zupancic Economic Evaluation Journal Club: PINT Trial Dmitry Dukhovny, MD MPH Instructor in Pediatrics, Harvard Medical School Neonatologist, Beth Israel Deaconess Medical Center Journal Club February 19, 2013 Conflicts of Interest I have no conflicts of interest Agenda Why Economic Evaluations? Brief overview of PINT Trial PINT EE by Kamholz et al. Objectives 1. To understand the key components of an economic evaluation 2. To identify sources to assist with critical appraisal of economic evaluations 3. To be able to critically assess an economic evaluation Why do an economic evaluation? SPR Workshop: Dollars and Sense Framing: Type of Analysis Costing Cost-minimization Cost-effectiveness Cost-utility Cost-benefit “Incomplete” Economic Evaluations “Complete” Economic Evaluations ? 2012 Dukhovny, Lorch, Profit, Kamholz, Zupancic Framing: Study Design Frankenstein’s Monster? Vampire of Trials? O’Brien B. Med Care. 1996;34(12 Suppl):DS99-108 Decision Analysis Randomized Trial Slide used with permission from J AF Zupancic SPR Workshop: Dollars and Sense Cost-Effectiveness Study Cost-Effectiveness = Costs of Treatment A – Costs of Treatment B Effects of Treatment A – Effects of Treatment B ? 2012 Dukhovny, Lorch, Profit, Kamholz, Zupancic PICOT P ELBW (BW1,000 g), GA31 wks, 48 hrs old at enrollment I transfusion algorithm C higher vs. lower threshold (depends on DOL, respiratory support and type of sample) O Primary: Death before d/c home or survival with BPD, severe ROP (3-5), Brain injury (PVL, ventriculomegally) Secondary: Death or CP, Cognitive Delay (MDI70), severe visual (20/200 in